Biological interpretation of genome-wide association studies using predicted gene functions

Citation:

Pers TH, Karjalainen JM, Chan Y, Westra H-J, Wood AR, Yang J, Lui JC, Vedantam S, Gustafsson S, Esko T, Frayling T, Speliotes EK, of Consortium GIANT (GIANT), Boehnke M, Raychaudhuri S, Fehrmann RSN, Hirschhorn JN, Franke L. Biological interpretation of genome-wide association studies using predicted gene functions [Internet]. Nat Commun 2015;6:5890.

Date Published:

2015 Jan 19

Abstract:

The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enriched pathways and identify tissues/cell types where genes from associated loci are highly expressed. DEPICT is not limited to genes with established functions and prioritizes relevant gene sets for many phenotypes.

Publisher's Version

Last updated on 04/29/2020