At the Raychaudhuri Lab, we study the basis of autoimmune disease using techniques in human genetics, bioinformatics, and systems biology.
Our group is in the Divisions of Genetics & Rheumatology in the Department of Medicine of the Brigham and Women's Hospital and Harvard Medical School. We are part of the Partners HealthCare Center for Personalized Genetic Medicine, and we are affiliated with the Program in Medical and Population Genetics at the Broad Institute and the Bioinformatics and Integrative Genomics graduate program at Harvard.
- Defining Inflammatory Cell States in Rheumatoid Arthritis Joint Synovial Tissues by Integrating Single-cell Transcriptomics and Mass Cytometry
- Lymphocyte innateness is defined by underlying transcriptional states reflecting a balance between proliferation and effector functions
- The eMERGE genotype set of 83,717 subjects imputed to ~40 million variants genome wide and association with the herpes zoster medical record phenotype
- Functional genomics of stromal cells in chronic inflammatory diseases.
- An Integrated Clinical Program and Crowdsourcing Strategy for Genomic Sequencing and Mendelian Disease Gene Discovery.
- Review: Genetics and the Classification of Arthritis in Adults and Children.