At the Raychaudhuri Lab, we study the basis of autoimmune disease using techniques in human genetics, bioinformatics, and systems biology.
Our group is in the Divisions of Genetics & Rheumatology in the Department of Medicine of the Brigham and Women's Hospital and Harvard Medical School. We are part of the Partners HealthCare Center for Personalized Genetic Medicine, and we are affiliated with the Program in Medical and Population Genetics at the Broad Institute and the Bioinformatics and Integrative Genomics graduate program at Harvard.
- Fast, sensitive, and accurate integration of single cell data with Harmony
- Distinct HLA associations with rheumatoid arthritis subsets defined by serological subphenotype
- Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39
- Cross-disorder analysis of schizophrenia and 19 immune-mediated diseases identifies shared genetic risk
- Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians
- The immune cell landscape in kidneys of patients with lupus nephritis