At the Raychaudhuri Lab, we study the basis of immune mediated disease using techniques in human genetics, bioinformatics, and systems biology.
Below, please click each figure to visit the associated publication.
Recent Publications
- Distinct HLA Associations with Rheumatoid Arthritis Subsets Defined by Serological Subphenotype
- Fast, sensitive and accurate integration of single-cell data with Harmony
- Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians
- Defining Inflammatory Cell States in Rheumatoid Arthritis Joint Synovial Tissues by Integrating Single-cell Transcriptomics and Mass Cytometry
- IMPACT: Genomic annotation of cell-state-specific regulatory elements inferred from the epigenome of bound transcription factors
- Lymphocyte innateness is defined by underlying transcriptional states reflecting a balance between proliferation and effector functions
Soumya Raychaudhuri's Twitter
-
Autoimmune variants were enriched in cell-state-dependent eQTLs, such as an RA variant near ORMDL3 strongest in cytotoxic CD8+ T cells. This suggests that cell state context is important for disease-associated eQTLs. t.co/OZwL7aulEn
-
In some instances, multiple independent SNP effects acting on the same gene might respond differently to cell-state differences. t.co/nU48rMsl0S
-
Over one-third of the 6,511 cis-eQTLs had state-dependent effects, which we could calculate at single-cell resolution. t.co/Db88w79feh
-
We modeled eQTLs with a Poisson mixed effects model robust to single-cell sparsity and differential expression that can occur with cell-state changes. t.co/dBL1Z1F2oE
-
Here, we modeled continuous T cell states at single-cell resolution by integrating RNA and 31 T cell surface proteins. t.co/C2CUjk7pmr
